I've often thought that if I were to boil down my set list to one word it would be issues. I think most every comic artist has issues that are the driving force behind the jokes, observations and rants,... if not perhaps they should be.
Issues are like mistakes; we all experience them, however real comics don't seem to live in fear of the next one. Comedy is that art form that is not only reflective but active in it's feelings it instills into painful moments.
Painters paint, musicians write songs, poets create poems.